Local application of IGF1 on dental pulp mechanically exposed; in vivo study on rabbit

Authors

  • M Haddad Department of Oral Pathology, St Joseph University, Faculty of Dental Medicine, Beirut, Lebanon
  • G Lefranc
  • G Aftimos

Abstract

IGF1 (Insulin Growth Factor, 1) was intentionally applied onto pulp tissues, aiming to provoque a dentine regeneration process through the stimulation of the dentinoblasts' potententials. 72 cavities were hence performed on rabbit molars, intentionally exposing the dental pulp. Different concentrations of IGF1 were then applied; The histo and anatomo-pathological observations showed persistent vitality of the pulp without any sign of necrosis, even 6 weeks after the IGF1 application. Dentinoblasts layers (as an indication of the regeneration activity) were counted, according to a pre-established protocol, at days 7, 14, 22, 28 and 42. The type of the applied IGF1, was carefully selected to be ";Binding Protein Resistant"; (IGF-BPR), so to avoid any inhibition of the IGF1 action by the endogenous binding proteins (Hochscheid and coll). The results were conclusive in indicating the IGF1 as an efficient dental pulp capping product.

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Published

2008-12-23

Issue

Vol. 45 No. 1 (2003)

Section

Original Research Articles

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