Ultrastructural analysis of periapical granulomas

A Piattelli, L Artese


A large portion of periapical granulomas is composed by cells of the mononuclear-phagocyte and lymphoid system. The ultrastructural features of the monocytes/macrophages differ in relationship to the state of activity of the cells (phagocytosis or secretion). A close correlation between cells of these two systems can be surmised by their tight contacts. An important role in the bone resorption is probably played by cytokines like IL-1 and TNF.


bone resorption; cytokines; monocytes/macrophages; periapical lesions; ultrastructure

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