Localization of proliferating cell nuclear antigen-immunoreactivity in human dental pulp and gingiva

Authors

  • A Casasco
  • M Casasco

Keywords:

proliferating cell nuclear antigen, dental pulp, gingiva, proliferation, human

Abstract

The proliferating cell nuclear antigen (PCNA) is regarded as an operational marker of proliferating cells. We have used PC10 monoclonal antibody to PCNA to reveal proliferation sites in human dental pulp and gingiva. Intense PCNA-immunoreactivity was observed in the basal layer of the gingiva lining epithelium and within some cells of the underlying connective tissues, including some endothelial and perivascular cells. PCNA-reactive cells were scattered throughout the pulp tissue, but were particularly numerous in the peripheral part. Since PCNA is an endogenous cell cycle-related molecule, we propose that PCNA-antibodies may represent useful tools for studying cell kinetics in human oral tissues in normal as well as pathological situations, such as tumors, wound healing and inflammation.

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Published

2020-04-17

Issue

Vol. 39 No. 3-4 (1996)

Section

Original Research Articles

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5. The copyright of the article is transferred from the authors to the Bulletin du Groupement International pour la Recherche Scientifique en Stomatologie et Odontologie upon acceptance of the manuscript.