Hypophosphatasia: Enzyme Replacement Therapy (Asfotase Alfa) Decreases TNSALP Substrate Accumulation And Improves Functional Outcomes In Affected Adolescents And Adults

Authors

  • M P Whyte Shriners Hospital for Children
  • P S Kishnani Duke University
  • C R Greenberg Shriners Hospital for Children
  • K Madson Shriners Hospital for Children
  • K Mack Shriners Hospital for Children
  • T Weber Duke University
  • A Mhanni University of Manitoba
  • H Plotkin Cambridge, MA
  • N Kreher
  • H Landy

Abstract

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Author Biographies

M P Whyte, Shriners Hospital for Children

Shriners Hospital for Children, St. Louis, MO

P S Kishnani, Duke University

Duke University, Durham , North Carolina

C R Greenberg, Shriners Hospital for Children

Shriners Hospital for Children, St. Louis, MO

K Madson, Shriners Hospital for Children

Shriners Hospital for Children, St. Louis, MO

K Mack, Shriners Hospital for Children

Shriners Hospital for Children, St. Louis, MO

T Weber, Duke University

Duke University, Durham, NC

A Mhanni, University of Manitoba

University of Manitoba, Winnipeg

H Plotkin, Cambridge, MA

Alexion Pharmaceuticals, Cambridge, MA

N Kreher

Alexion Pharmaceuticals, Cambridge, MA

H Landy

Alexion Pharmaceuticals, Cambridge, MA

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Published

2012-07-31

Issue

Vol. 51 No. 1 (2012): The 6th International Alkaline Phosphatase and Hypophosphatasia Symposium

Section

Actae of Congresses

License

I hereby certify that the authors of the above manuscript have all:

1. Conceived, planned, and performed the work leading to the report, or interpreted the evidence presented, or both;

2. Written the report or reviewed successive versions and shared in their revisions; and

3. Approved the final version.

Further, I certify that:

1. This work has not been published elsewhere and is not under revision in another journal;

2. Humane procedures have been followed in the treatment of experimental animals (if applicable);

3. Investigations in humans was done in accordance with the ethical standards of the responsible committee on human experimentation or with the Helsinki Declaration (if applicable).

4. This paper has been carefully read by a native English speaker who is familiar with the field of work (this applies to authors who are not fluent in English); and

5. The copyright of the article is transferred from the authors to the Bulletin du Groupement International pour la Recherche Scientifique en Stomatologie et Odontologie upon acceptance of the manuscript.