Impact of three endocrine disruptors, Bisphenol A, Genistein and Vinclozolin on female rat enamel

Katia Jedeon, A. Berdal, A. Babajko


Concerns about the potential adverse effects
of endocrine disruptors (EDs) have been increasing
over the last three decades. Bisphenol
A (BPA), genistein (G) and vinclozolin (V) are
three widely used EDs sharing similar effects.
Since populations are exposed to many diverse
EDs simultaneously, we demonstrated
recently their impact alone or combined on
male rat tooth enamel. The purpose of this
study was therefore to assess their effects on
female rat tooth enamel in order to understand
why they are differentially sensitive. Rats
were exposed daily in utero and after birth to
low doses of EDs during the critical fetal and
suckling periods when amelogenesis takes
place. Enamel of rats exposed to EDs presented
opaque areas of hypomineralization. The
proportion of affected rats was the highest
in the groups of rats treated with BPA alone
and higher in males than in females (in all the
groups). Comparison of enamel key gene expression
levels showed modulations of Klk4
and Enamelin in males but no significant variations
in females. These findings show that
female rats are less affected than males by
the three EDs chosen in this study and suggest
that enamel hypomineralization may differ
between males and females


Endocrine disruptor, bisphenol A, genistein, vinclozolin, enamel, hypomineralization, female rat.


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