Detection of HPV DNA by in situ hybridization in benign, premalignant and malignant lesions of the oral mucosa

M.A González-Moles, I Ruiz-Avila, S González-Moles, I Martinez, A Ceballos, F Nogales

Abstract


Evidence has accumulated in recent years that relates certain types of human papillomaviruses (HPV) to the development of some tumors. We use in situ hybridization to study DNA from HPV 6/11, 16/18 and 31/33/35 in 6 squamous papillomas, 18 hyperkeratotic/acanthosis lesions with and without dysplasia (5 and 13 cases respectively) and 27 squamous cell carcinomas of the oral mucosa. HPV DNA was found in 66% of squamous papillomas, 38.4% of hyperkeratotic/acanthosis lesions without dysplasia, 60% of epithelial dysplasia and 37% of squamous cell carcinomas. HPV DNA 6/11 was the most common type found, and in squamous cell carcinomas HPV DNA appear more frequently in well differentiated tumors.


Keywords


HPV-DNA; in situ hybridization; oral mucosa

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