Influence of a hypoiodite mouth-wash on dental plaque formation in vivo

A Vanden Abbeele, H De Meel, Ph Courtois, M Pourtois

Abstract


This study describes an in vivo inhibition of dental plaque growth after peroxidase-generated hypoiodite (OI-) mouth-washes. After giving up ail other usual hygiene procedures nine healthy volunteers washed their mouth using 10 ml of the mouth-wash [H2O2 (0.005%), Kl (50 mM) and lactoperoxidase (0.04%)] three times a day for 1 minute for 3 days. The initial oxidation power of this mixture represented 430 ±11 µM oxidised cysteine (n=6), dropping down to 87 ± 6 µM after the solution was spat out (n=5). A saline solution served as a negative control, and a 0.2% chlorhexidine digluconate solution as a positive control. Proximal dental plaque between mandibular canine and lateral incisor (left and right) was collected after 3 days using standardized sterile toothpicks, then analysed for ATP and protein content. ATP concentrations dropped to 49% of the control values after OI- rinsing, and to 9% after chlorhexidine rinsing while the protein content dropped to 48% for OI- versus 31 % for chlorhexidine. However, when considering the ATP content per protein µg, only the decrease to 6% of the initial value in the chlorhexidine testing was significant while the drop to 81% for the OI- testings was not significant. This study points out a negative effect of OI- on plaque growth in vivo.

Keywords


peroxidase; hypoiodite; dental plaque; ATP

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