Behaviour of adenylic and pyridinic compounds in gingival tissue after a short-term exposure to air

L Fonzi, M Belli, R Sonderegger, V Kaitsas, C Santacroce, G Passagrilli


Biochemical variations of adenine and pyridine compounds in human gingival grafts during the period between excision and implantation have been studied. These groups of compounds are considered as «indicators» of the metabolic and energetic status of the living cells. Adenylic compounds such as ATP, ADP and AMP are involved in numerous metabolic processes as «modulators» of allosteric enzymes.

NAD+ and NADP+ are involved in the carbohydrate metabolism as co-factors of many reactions of oxydoreduction. The exposure to air of the gingival tissue induces modifications in the energy state of the cells as well as in the ox-reox system. No variation is detectable in the intermediates of the pyridine compounds cycle.


human gingival tissue; adenylic compounds; pyridinic compounds; HPLC

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