Activité bactericide de bains de bouche contenant 0,10%, 0,12% et 0,20% de digluconate de chlorhexidine
Keywords:chlorhexidine, mouthrinses, periodontitis, bactericidal activity, antisepsis
AbstractAntiseptic activity of five mouthrinses containing 0.10%, 0.12% and 0.20% chlorhexidine, as well as aqueous chlorhexidine solutions at the same concentrations were determined under usual conditions (advocated dilutions by the manufacturers and short contact time) and according to French Pharmacopoea recommandations. The three aqueous solutions and two mouthrinses containing 0.12% chlorhexidine were not antiseptic according to the fixed criterions. Bactericida! activities of the different dilutions of products were tested with an approppriate micromethod against ninebacterials species involved in periodontal disease. Efficacity of mouthrinses were variable and were not agreed with the aqueous chlorhexidinecorresponding solutions: the mouthrinse containing 0.10% chlorhexidine reached 0.20% aqueous solution efficacy, and the mouthrinses containing 0.12% chlorhexidine were generally less active than the 0.12% aqueous chlorhexidine solution. Therefore, antibacterial activity of this type of product cannot be anticipated with the sole concentration factor, excipients playing essential part in the chlorhexidine activity.
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