Activité bactericide de bains de bouche contenant 0,10%, 0,12% et 0,20% de digluconate de chlorhexidine

Auteurs-es

  • Joelle Luc
  • Christian Mroz
  • Christine Roques
  • Marie Ducani - Federlin

Mots-clés :

chlorhexidine, mouthrinses, periodontitis, bactericidal activity, antisepsis

Résumé

Antiseptic activity of five mouthrinses containing 0.10%, 0.12% and 0.20% chlorhexidine, as well as aqueous chlorhexidine solutions at the same concentrations were determined under usual conditions (advocated dilutions by the manufacturers and short contact time) and according to French Pharmacopoea recommandations. The three aqueous solutions and two mouthrinses containing 0.12% chlorhexidine were not antiseptic according to the fixed criterions. Bactericida! activities of the different dilutions of products were tested with an approppriate micromethod against ninebacterials species involved in periodontal disease. Efficacity of mouthrinses were variable and were not agreed with the aqueous chlorhexidinecorresponding solutions: the mouthrinse containing 0.10% chlorhexidine reached 0.20% aqueous solution efficacy, and the mouthrinses containing 0.12% chlorhexidine were generally less active than the 0.12% aqueous chlorhexidine solution. Therefore, antibacterial activity of this type of product cannot be anticipated with the sole concentration factor, excipients playing essential part in the chlorhexidine activity.

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Publié-e

2021-04-06

Numéro

Vol. 40 No. 2-3 (1998)

Rubrique

Original Research Articles

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I hereby certify that the authors of the above manuscript have all:

1. Conceived, planned, and performed the work leading to the report, or interpreted the evidence presented, or both;

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Further, I certify that:

1. This work has not been published elsewhere and is not under revision in another journal;

2. Humane procedures have been followed in the treatment of experimental animals (if applicable);

3. Investigations in humans was done in accordance with the ethical standards of the responsible committee on human experimentation or with the Helsinki Declaration (if applicable).

4. This paper has been carefully read by a native English speaker who is familiar with the field of work (this applies to authors who are not fluent in English); and

5. The copyright of the article is transferred from the authors to the Bulletin du Groupement International pour la Recherche Scientifique en Stomatologie et Odontologie upon acceptance of the manuscript.